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  • Evidence is increasing that every addiction without exception is related to difficulty with the brain's reward center, particularly the mesolimbic system. This part of the problem regulates reward responses in acquiring food and sex, as well as in nurturing infants and children. One of the most important neurotransmitters involved with reward responses, both after they malfunction and after they function properly, is dopamine. What makes opiates unique is that it, among other neurotransmitters modulates "the quantity of dopamine released in in reaction to a stimulus"(Bostwick & Bucci, 2008). Using two separate drugs to lose weight can be very effective there are combinations before the FDA now awaiting approval. When dealing with weight loss and the individuals who go through it you ought to err assisting caution and allow the FDA do its job and demand some research be done so the public understands the side effects and hazards of the medications before we bring them. Keep in mind that drug companies will be in business to generate income and that they would say almost anything to keep people on the medications. Researchers found out that participants investing in this drug for the year, lost weight within one month and have kept the load off throughout the 56 weeks from the study. Contrave is really a combination in the drugs naltrexone and bupropion, which seems to reflect a new trend of weight-loss drugs which can be made up of more than one active ingredient, which might make them more efficient and safer. Combo-pilling is the newest fad or even better the newest into the future under scrutiny and for that reason it is just more publicly known in recent months, comb-pilling to lose weight has been around since the eighties. The biggest reason that using a combination of pills is now popular will be the fact that by right now there are no long term prescription weightloss pills that have been licensed by the FDA aside from orlistat. The truly disturbing part is that doctors are prescribing these combinations of medications however some of the combinations are actually rejected or have yet to be licensed by the FDA. Seizures can be a side effect with Contrave and really should not be taken in individuals with seizure disorders. The drug can also raise blood pressure levels and heartrate, and mustn't be used in those with a history of heart attack or stroke in the earlier six months. Blood pressure and pulse should also be measured before beginning the drug and throughout therapy with the drug. The FDA also warned that Contrave can raise blood pressure levels and heart rate and must stop used in patients with uncontrolled high blood pressure level, along with by anyone with heart-related and cerebrovascular (circulation dysfunction impacting the brain) disease. Patients having a history of cardiac arrest or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded in the clinical trials. Those taking Contrave needs to have their heart-rate and pulse monitored regularly. In addition, since the compound includes bupropion, Contrave comes having a boxed warning to alert medical professionals and patients for the increased chance of suicidal thoughts and behaviors linked to antidepressant drugs. The warning also notes that serious neuropsychiatric events are actually reported in patients taking bupropion for smoking cessation. The most common unwanted effects with Contrave include nausea, constipation, headache, vomiting, dizziness, insomnia, dry mouth, and diarrhea.

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